Chapter 1: Literature Review
- Fetal Programming/Fetal Origins of Adult Disease
- Fetal Alcohol Syndrome
- Growth Retardation
- Symmetrical vs. Asymmetrical
- Causes (Ethanol, Malnutrition, Genetic Disorders, other teratogens (smoking, caffeine??)) - compare & contrast
- Symmetrical vs. Asymmetrical
- Fetal Bone Development
- Endochondral vs. Intramembranous
- Stages of Endochondral Bone Development
- Factors Regulating Endochondral Bone Development
- Endochondral vs. Intramembranous
- Calcium Regulation
- normal
- during pregnancy
- fetal
- normal
- Animal Models
- Animal Models of Fetal Alcohol Syndrome
- pros & cons of different methods of E administration
- comparing animal models to humans (BAC issue; trimester issue?)
- pros & cons of different methods of E administration
- Animal Models of Fetal Bone Development
- pros & cons of different species
- Animal Models of Fetal Alcohol Syndrome
- Thesis Objectives
Chapter 2: Dose Response Paper
Chapter 3: Histology Paper
Chapter 4: Discussion
- Discussion and conclusions relating manuscript chapters to each other and to the discipline or field of study
- Strengths/limitations
- Future Directions
- Elucidating Mechanisms (immunohistochemistry; DNA microarry, intramembranous ossification, calcium supplementation/deficiency)
- Biomarker for alcohol exposure for diagnosis of ARND (how specific is the bone effect? how sensitive?)
- Fetal programming (potential for long term effects)
- Bone fracture repair?
- Calcification of the artery during atherosclerosis recapitulates endochondral ossification – would ethanol affect it?
- Elucidating Mechanisms (immunohistochemistry; DNA microarry, intramembranous ossification, calcium supplementation/deficiency)
- figures not included in Dose Response Paper
- figures not included in Histology Paper (if any)
- Animal Care certificates
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